Association of critically short telomeres with brain and blood markers of ageing and Alzheimer’s disease in older adults
Although an increase in %CST does not appear to be directly linked to the pathophysiology of AD in cognitively healthy older adults, it could heighten the susceptibility of APOE4 carriers to develop AD plausibly due to greater vulnerability to age-related effects. However, longitudinal studies would be necessary to determine whether %CST influences the development and progression of AD later in life.
Authors
- F. Colette
- Stéphane Rehel
- Antoine Lutz (ORCID: https://orcid.org/0000-0002-0258-3233)
- Denis Vivien (ORCID: https://orcid.org/0000-0002-7636-2185)
- Claire André (ORCID: https://orcid.org/0000-0001-7077-1108)
- Léo Paly
- Gaël Chételat (ORCID: https://orcid.org/0000-0002-4889-7932)
- Séverine Fauvel
- Vincent de La Sayette (ORCID: https://orcid.org/0000-0003-0663-092X)
- Éric Salmon (ORCID: https://orcid.org/0000-0003-2520-9241)
- Natalie L. Marchant (ORCID: https://orcid.org/0000-0003-0669-6910)
- Gwendoline Le Du
- Géraldine Poisnel (ORCID: https://orcid.org/0000-0001-7943-1281)
- Marion Delarue (ORCID: https://orcid.org/0000-0002-8934-8649)
- Marc Heidmann
- Olga Klimecki (ORCID: https://orcid.org/0000-0003-0757-7761)
- Stefano Poletti (ORCID: https://orcid.org/0000-0001-8320-3193)
- Elizabeth Kuhn (ORCID: https://orcid.org/0000-0002-3744-1155)
- Anne Quillard
- Eider M. Arenaza‐Urquijo (ORCID: https://orcid.org/0000-0001-7016-7576)
- Edelweiss Touron (ORCID: https://orcid.org/0000-0001-7906-934X)
- Caitliin Ware
- E Devouge
- Miranka Wirth (ORCID: https://orcid.org/0000-0002-0725-7314)
- P A Kaliman (ORCID: https://orcid.org/0009-0006-4299-4316)
- Robin de Florès (ORCID: https://orcid.org/0000-0003-3953-3392)
- Patrik Vuilleumier (ORCID: https://orcid.org/0000-0002-8198-9214)
- Florence Mézenge
- Valentin Ourry (ORCID: https://orcid.org/0000-0002-8535-9009)
- Francesca Felisatti
- Brigitte Landeau (ORCID: https://orcid.org/0000-0002-0814-3714)
- Frank Jessen (ORCID: https://orcid.org/0000-0003-1067-2102)
- Inès Moulinet
- Matthieu Vanhoutte (ORCID: https://orcid.org/0000-0001-9860-8193)
- Agathe Vrillon (ORCID: https://orcid.org/0000-0002-0761-7885)
- Valérie Lefranc
- Pierre Champetier (ORCID: https://orcid.org/0000-0003-0228-6084)
- Géraldine Rauchs
- Antoine Garnier‐Crussard (ORCID: https://orcid.org/0000-0002-5611-3608)
- Anne Chocat
- Siya Sherif (ORCID: https://orcid.org/0000-0002-3731-5685)
- Julie Gonneaud (ORCID: https://orcid.org/0000-0003-0566-5581)
- Cassandre Palix (ORCID: https://orcid.org/0000-0001-8736-5261)
- Asrar Lehodey
- Anne‐Laure Turpin
- Claire Paquet (ORCID: https://orcid.org/0000-0002-2273-7316)
Institutions
- Universitat Oberta de Catalunya (ES)
- Inserm (FR)
- Université Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Normandie Université (FR)
- Hôpital Fernand-Widal (FR)
- Centre Hospitalier Universitaire de Caen Normandie (FR)
- Hôpital Lariboisière (FR)
- Cyceron (FR)
- Physiopathologie et imagerie des troubles neurologiques
- Université de Caen Normandie (FR)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1186/s13195-024-01635-0
- Citations
- 3
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.98
Funders
- European Commission
- Institut National de la Santé et de la Recherche Médicale
- Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche
- Région Normandie