Artesunate disrupts ribosome RNA biogenesis and inhibits ovarian cancer growth by targeting FANCA
These findings establish ART as a potent inhibitor of ribosome biogenesis, presenting a promising therapeutic avenue for ovarian tumors with high FANCA expression or for cancer patients exhibiting abnormal activation of the mTOR-RPS6 pathway.
Authors
- Xialin Zhu
- Fei Li (ORCID: https://orcid.org/0000-0001-9813-643X)
- Hongyan Liu (ORCID: https://orcid.org/0000-0003-2008-1787)
- Xiaoli Ma (ORCID: https://orcid.org/0000-0003-0279-8354)
- Hongxing Li (ORCID: https://orcid.org/0000-0002-8178-4622)
- Xiaoting Liu (ORCID: https://orcid.org/0000-0002-9859-4489)
- Yuyan Wei (ORCID: https://orcid.org/0000-0002-2361-1563)
- Fengying Liu
Institutions
- Shanghai Medical College of Fudan University (CN)
- Qilu University of Technology (CN)
- Jinan Central Hospital (CN)
- Shandong Academy of Sciences (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1016/j.phymed.2024.156333
- Citations
- 9
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.10