Toxicological Assessment of Murraya Koenigii Fruit Extract: Acute and Subacute Evaluation in experimental animals

The current investigation was aimed to assess anti-anaphylactic, and anti-asthmatic activity of aqueous extract of psidium guajava (Myrtaceae) on experimental animals. Anaphylaxis was induced by administration of horse serum subcutaneously in albino Wistar rats. Extracts of psidium guajava were administered to the rats in dose of 125,250 and 350 mg/kg b.w. orally for 14 days. At the end of treatment, we assessed the modulatory effect on experimentally induced airway inflammation in rats. The effect of psidium guajava on oxidative stress, TNF-α and lung histopathology. Anti-asthmatic activity of extracts of psidium guajava was also studied on Milk induced eosinophilia and leukocyte count model. The treatment with extracts of psidium guajava produced significant decrease in eosinophils and leukocyte count. Thus, these findings concluded that psidium guajava could be effectively used in the treatment of anaphylaxis and asthma.