Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3
This study confirms the existence of two hsa-miR-214-3p binding sites on the 3' UTR of B7H3, reinforcing the role of hsa-miR-214-3p as a regulatory factor for B7H3. In breast cancer, hsa-miR-214-3p reduces tumor cell proliferation and enhances the tumor immune microenvironment by downregulating B7H3. These findings suggest new potential targets for the clinical treatment of breast cancer.
Authors
- Xin-Hua Sheng
- Yuanhong Peng (ORCID: https://orcid.org/0000-0003-2733-2550)
- Lei Huang (ORCID: https://orcid.org/0000-0003-3881-5902)
- Zhiwei He (ORCID: https://orcid.org/0000-0002-3251-8731)
- Yan Lü (ORCID: https://orcid.org/0000-0002-5893-6114)
- Manzhao Ouyang (ORCID: https://orcid.org/0000-0002-2802-8342)
- Lin Zhong (ORCID: https://orcid.org/0000-0002-1822-6919)
- Meng Chen (ORCID: https://orcid.org/0000-0002-2449-5904)
- Kang Wang (ORCID: https://orcid.org/0000-0002-4963-2979)
- Xin Yang (ORCID: https://orcid.org/0000-0001-8509-9959)
- George A. Calin
- Fan-E Cheng
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Guangdong Medical College (CN)
- The First People's Hospital of Shunde (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
- Published
- 2024-12-20
- DOI
- https://doi.org/10.32604/or.2024.057472
- Citations
- 5
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.43