Associations Between the Polymorphisms in the Coding Sequence of SLCO1B1 and Blood Lipid Levels Before and After Treatment by Atorvastatin in the Chinese Han Adults with Dyslipidemia
This study delved into the intricate genetic structure of polymorphisms in SLCO1B1 CDS and their roles in lipid metabolism and atorvastatin's efficacy among Chinese Han adults with dyslipidemia. The findings underscore the crucial role of the rs2306283 polymorphism in the response to atorvastatin's efficacy, highlighting the significance of pharmacogenomics in personalized medicine. It is thus advisable to consider genetic testing for SLCO1B1 variants to optimize atorvastatin therapy.
Authors
- Songnian Hu (ORCID: https://orcid.org/0000-0003-3966-3111)
- Jia Fu (ORCID: https://orcid.org/0000-0002-8280-3813)
- Guoqiang Zhang
- Ningling Sun (ORCID: https://orcid.org/0000-0003-0378-2813)
- Chao Chen (ORCID: https://orcid.org/0000-0002-4927-0234)
- Yanwei Zhang (ORCID: https://orcid.org/0000-0002-0230-6279)
- Qian Li (ORCID: https://orcid.org/0000-0002-5143-826X)
- M Feng
- Ji Zheng
- Yan Tian
Institutions
- Chinese Academy of Sciences (CN)
- Peking University (CN)
- Microbiology Institute of Shaanxi (CN)
- Peking University People's Hospital (CN)
- Institute of Microbiology (CN)
- PharmacoGenetics (China) (CN)
- OriginWater (China) (CN)
- University of Chinese Academy of Sciences (CN)
- Tangshan Gongren Hospital (CN)
Publication Details
- Journal
- Pharmacogenomics and Personalized Medicine
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/pgpm.s482289
- Citations
- 2
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- Chinese Academy of Sciences
- State Key Laboratory of Microbial Resources
- Institute of Microbiology, Chinese Academy of Sciences