Metabolomic signature of pediatric diabetic ketoacidosis: key metabolites, pathways, and panels linked to clinical variables
These findings underscore significant metabolic disturbances in severe DKA and their associations with critical clinical indicators. Future investigations should explore if metabolic alterations in severe DKA can identify patients at increased risk of complications and/or guide future therapeutic interventions.
Authors
- Saverio Stranges (ORCID: https://orcid.org/0000-0001-5226-8373)
- Gediminas Cepinskas (ORCID: https://orcid.org/0000-0002-0267-6659)
- Douglas D. Fraser (ORCID: https://orcid.org/0000-0002-5635-3791)
- M. Bravo
- Mark Daley (ORCID: https://orcid.org/0000-0002-6939-9772)
- Enis Cela
- C. Anthony Rupar (ORCID: https://orcid.org/0000-0002-0969-9415)
- Cheril Clarson (ORCID: https://orcid.org/0000-0003-0553-6915)
- P. Spagnolo (ORCID: https://orcid.org/0000-0001-7962-5203)
- David Tweddell
Institutions
- Western University (CA)
- Università Campus Bio-Medico (IT)
- London Health Sciences Centre (CA)
- Hospital for Sick Children (CA)
- Federico II University Hospital (IT)
- Institute of Child Health (IN)
- Children’s Health Research Institute (CA)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1186/s10020-024-01046-9
- Citations
- 4
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 1.31
Funders
- Academic Medical Organization of Southwestern Ontario
- London Health Sciences Foundation