EZH2/miR-142-3p/HMGB1 axis mediates chondrocyte pyroptosis by regulating endoplasmic reticulum stress in knee osteoarthritis
A novel EZH2/miR-142-3p/HMGB1 axis mediates chondrocyte pyroptosis and cartilage degeneration by regulating ER stress in OA, contributing novel mechanistic insights into OA pathogenesis and providing potential targets for future therapeutic research.
Authors
- Shan‐Shan Dong (ORCID: https://orcid.org/0000-0001-6976-4576)
- Yanrong Lu
- Xin Zeng (ORCID: https://orcid.org/0000-0001-9649-1323)
- Guangneng Liao (ORCID: https://orcid.org/0000-0002-5753-827X)
- Haibo Si (ORCID: https://orcid.org/0000-0002-4697-5597)
- Yang Chen (ORCID: https://orcid.org/0000-0003-0164-7079)
- Lan Li (ORCID: https://orcid.org/0000-0001-8401-4001)
- Mingwei Liang (ORCID: https://orcid.org/0000-0002-5206-1353)
- Bin Shen (ORCID: https://orcid.org/0000-0002-6441-2958)
- Qing Xu
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Chinese Medical Journal
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1097/cm9.0000000000003186
- Citations
- 4
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.94