Activation of Imprinted Gene <i>PW1</i> Promotes Cardiac Fibrosis After Ischemic Injury
This study demonstrates that <i>Pw1</i> imprinting is disrupted after injury and reveals a novel role for the downstream target PFAS in ECM production and cardiac fibrogenesis. Targeting the PW1/PFAS signaling pathway presents a promising therapeutic strategy for improving cardiac repair after injury.
Authors
- Juan Tang (ORCID: https://orcid.org/0000-0002-0098-0403)
- Jufeng Meng (ORCID: https://orcid.org/0000-0002-3035-7225)
- Lieyang Qin (ORCID: https://orcid.org/0000-0002-7412-1687)
- Chao‐Po Lin (ORCID: https://orcid.org/0000-0002-1457-1635)
- Shan Shan Kou (ORCID: https://orcid.org/0000-0001-9833-3679)
- Xiajun Li
- Hui Zhang (ORCID: https://orcid.org/0000-0002-7038-5407)
- Min Ye (ORCID: https://orcid.org/0000-0003-1065-0034)
- Sui Yu (ORCID: https://orcid.org/0009-0009-5654-5636)
- Zhengkai Lu (ORCID: https://orcid.org/0009-0009-2166-9970)
- Defang Deng
- Zhen Jiang (ORCID: https://orcid.org/0000-0001-7607-5955)
- Teng Feng (ORCID: https://orcid.org/0000-0002-4442-7327)
- Chen Liu (ORCID: https://orcid.org/0009-0000-7349-8610)
Institutions
- Fudan University (CN)
- ShanghaiTech University (CN)
- Zhongshan Hospital (CN)
- Shanghai East Hospital (CN)
- Shanghai Clinical Research Center (CN)
Publication Details
- Journal
- Circulation
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1161/circulationaha.124.070738
- Citations
- 11
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.57