Berberine promotes primordial follicle activation and increases ovulated oocyte quantity in aged mice
BBR promotes mouse and human primordial follicle activation through the PI3K/Akt pathway in oocytes, and improves the quantity of ovulated oocytes in aged mice. Our results suggest a potential use of oral medicine BBR to improve fertility in POI patients and aged women.
Authors
- Hongwei Wei
- Weiyong Wang (ORCID: https://orcid.org/0000-0002-8607-3379)
- Yashuang Weng
- Shuang Liu (ORCID: https://orcid.org/0000-0003-3301-6925)
- Xiaodan Zhang (ORCID: https://orcid.org/0000-0002-2606-338X)
- Ye Chen (ORCID: https://orcid.org/0000-0002-7964-7899)
- Meijia Zhang (ORCID: https://orcid.org/0000-0001-7803-3054)
- Yahong Wang (ORCID: https://orcid.org/0000-0003-3214-8766)
- Wenjun Zhou (ORCID: https://orcid.org/0009-0009-1865-7514)
- Sihui He
- Huiyu Liu (ORCID: https://orcid.org/0000-0003-4465-8501)
- Xin Chen (ORCID: https://orcid.org/0000-0001-7407-2929)
Institutions
- The First People's Hospital of Shunde (CN)
- Southern Medical University (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1186/s10020-024-01042-z
- Citations
- 5
- Primary Topic
- Berberine and alkaloids research
- Type
- article
- Field-Weighted Citation Impact
- 2.24
Funders
- Innovative Research Group Project of the National Natural Science Foundation of China
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Basic and Applied Basic Research Foundation of Guangdong Province