A New Three-Hit Mouse Model of Neurodevelopmental Disorder with Cognitive Impairments and Persistent Sociability Deficits
Our work confirms the usefulness of a three-hit combination to model, particularly for negative-like symptoms associated with schizophrenia and other psychiatric disorders. The model therefore gathers powerful construct and face validities and supports an involvement of glutamate dysfunction in behavioral symptoms.
Authors
- Michel Boulouard (ORCID: https://orcid.org/0000-0003-3825-8659)
- Caroline Lahogue (ORCID: https://orcid.org/0000-0001-6571-8599)
- Valentine Bouët (ORCID: https://orcid.org/0000-0002-0857-2295)
- Thomas Fréret (ORCID: https://orcid.org/0000-0002-4446-4451)
- Thomas Cailly (ORCID: https://orcid.org/0000-0002-5262-4494)
- Imane Mouffok
Institutions
- Inserm (FR)
- COMETE - Mobilités : Vieillissement, pathologie, santé (FR)
- Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine (FR)
- Normandie Université (FR)
- Centre Hospitalier Universitaire de Caen Normandie (FR)
- Cyceron (FR)
- Centre d'Etudes et de Recherche sur le Médicament de Normandie
- Université de Caen Normandie (FR)
Publication Details
- Journal
- Brain Sciences
- Published
- 2024-12-20
- DOI
- https://doi.org/10.3390/brainsci14121281
- Citations
- 1
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.16
Funders
- Institut National de la Santé et de la Recherche Médicale
- Université de Caen Normandie
- Région Normandie