Proximity Proteomics Reveals USP44 Forms a Complex with BRCA2 in Neuroblastoma Cells and Is Required to Prevent Chromosome Breakage
Our results identified novel potential binding partners and potential substrates for USP44, including several with direct roles in cancer pathogenesis. Our results identified a novel association between BRCA2 and USP44, and a previously unknown role for USP44 in the Fanconi anemia DNA repair pathway that may contribute to its role in cancer.
Authors
- Danielle G. May (ORCID: https://orcid.org/0000-0002-2628-4414)
- Asma Ali (ORCID: https://orcid.org/0009-0007-7686-4824)
- Paul J. Galardy (ORCID: https://orcid.org/0000-0002-0322-8882)
- Sajjad Hussain (ORCID: https://orcid.org/0000-0002-4842-3702)
- Kyle J. Roux (ORCID: https://orcid.org/0000-0001-7530-5528)
- Raok Jeon (ORCID: https://orcid.org/0000-0002-3857-4339)
- Tibor Bedekovics (ORCID: https://orcid.org/0009-0003-9027-2324)
Institutions
- Mayo Clinic (US)
- University of South Dakota (US)
- WinnMed (US)
- Sanford Research (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Biomedicines
- Published
- 2024-12-20
- DOI
- https://doi.org/10.3390/biomedicines12122901
- Citations
- 1
- Primary Topic
- Biotin and Related Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.33
Funders
- Mayo Clinic