Acute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage
Acute systemic macrophage depletion reduced the levels of pro-inflammatory macrophages in the DRG and alleviated pain-related behaviors in established surgically induced OA in mice of both sexes, without affecting joint damage. Overall, these studies provide insight into immune cell regulation in the DRG during OA.
Authors
- Lai Wang (ORCID: https://orcid.org/0000-0002-3323-7210)
- Rahel S. Hunter
- Rachel E. Miller
- Terese Geraghty (ORCID: https://orcid.org/0000-0001-6496-7155)
- Anne‐Marie Malfait
- Frank C. Ko
- Hoomin Lee (ORCID: https://orcid.org/0000-0002-9404-3188)
- Natalie S. Adamczyk
- Alia M. Obeidat (ORCID: https://orcid.org/0009-0007-9864-0119)
- Jun Li (ORCID: https://orcid.org/0000-0003-1161-8490)
- Shingo Ishihara
Institutions
- Rush University Medical Center (US)
- Chicago Anesthesia Pain Specialists (US)
- Rush University (US)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1186/s13075-024-03457-9
- Citations
- 8
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- Rush University
- National Institute of Arthritis and Musculoskeletal and Skin Diseases