Histopathological Changes in Cryptorchidism of Infertile Patients Undergoing Intracytoplasmic Sperm Injection

Cryptorchidism may cause histological changes such as testicular atrophy or fibrosis, or even carcinoma in situ of the testis or testicular malignancy. Early diagnosis of such changes can enable proper management, such as performing orchidectomy or localized irradiation, which can save the life of the patient. The present study included a retrospective evaluation of the biopsies of patients with cryptorchidism who underwent Intracytoplasmic sperm injection (ICSI) to evaluate the prevalence of such changes in the testis. The testicular biopsies of 20 patients with a history of cryptorchidism were stained with H&E specimens. It was concluded that cryptorchidism leads to severe changes that predispose to infertility, and delays in orchidopexy cause more severe changes.