Mutation on JmjC domain of UTX impaired its antitumor effects in pancreatic cancer via inhibiting G0S2 expression and activating the Toll-like signaling pathway
In conclusion, UTX mutant weakened the antitumor effect of wild-type UTX in PC by inhibiting G0S2 expression and activating the Toll-like signaling pathway.
Authors
- Yiye Wan
- Xiaohua Shen (ORCID: https://orcid.org/0000-0002-4590-1502)
- Shan Lu
- Shuping Xiong (ORCID: https://orcid.org/0000-0003-1549-515X)
- Sheng-peng Wang
- Huiqing Zhang (ORCID: https://orcid.org/0000-0002-9137-9671)
Institutions
- Nanchang University (CN)
- Jiangxi Provincial Cancer Hospital (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1186/s10020-024-01023-2
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.47