GLUT1 exacerbates trophoblast ferroptosis by modulating AMPK/ACC mediated lipid metabolism and promotes gestational diabetes mellitus associated fetal growth restriction
Our findings suggest a potential role of ferroptosis in GDM associated FGR and indicate that the dysregulated GLUT1-AMPK-ACC axis may be involved in the pathogenesis of GDM associated FGR in clinicals.
Authors
- Wei Chu
- Qin Zhang (ORCID: https://orcid.org/0000-0002-9845-4099)
- Hui Li (ORCID: https://orcid.org/0000-0002-7516-7126)
- Yiran Li (ORCID: https://orcid.org/0000-0002-4658-3876)
- Hongbo Qi (ORCID: https://orcid.org/0000-0002-1169-4787)
- Qi Yao (ORCID: https://orcid.org/0000-0002-9813-4650)
- Xi Yuan
- Philip N. Baker
- Xiaojin Luan
- Ting Zhou Lei
Institutions
- Army Medical University (CN)
- University of Leicester (GB)
- Chongqing University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Southwest Hospital (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1186/s10020-024-01028-x
- Citations
- 24
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 5.61
Funders
- National Natural Science Foundation of China
- State Administration of Foreign Experts Affairs
- National Key Research and Development Program of China