Diagnostic interobserver variability of atypia assessment in columnar cell lesions among a group of expert breast pathologists in the United Kingdom and the Republic of Ireland, on behalf of the <scp>UK</scp> national coordinating committee for breas
Among expert breast pathologists, interobserver agreement in the diagnosis of atypia in CCLs was higher in cases with classical features of FEA. Consensus was difficult to achieve if nuclear or architectural atypia fell outside the classical definition of FEA, suggesting that this category does not encompass the range of low-grade cytological atypia in CLLs. This study provides rationale for expanding the definition of atypia in CCLs other than FEA.
Authors
- Madhuri Warren (ORCID: https://orcid.org/0009-0004-3609-9046)
- Rebecca Millican‐Slater (ORCID: https://orcid.org/0000-0001-6280-4598)
- Abeer M. Shaaban (ORCID: https://orcid.org/0000-0001-5784-8705)
- Cecily Quinn (ORCID: https://orcid.org/0000-0001-8920-5480)
- Emad A. Rakha (ORCID: https://orcid.org/0000-0002-5009-5525)
- Soha El Sheikh (ORCID: https://orcid.org/0000-0003-4661-1563)
- Rahul Deb (ORCID: https://orcid.org/0000-0001-9085-6918)
- Elena Provenzano (ORCID: https://orcid.org/0000-0003-3345-3965)
- Susan Pritchard (ORCID: https://orcid.org/0000-0001-6209-6050)
- Ian Ogilvie Ellis (ORCID: https://orcid.org/0000-0001-5292-8474)
- Mohamed A Mansour (ORCID: https://orcid.org/0000-0002-4558-5634)
- Clinton Boyd (ORCID: https://orcid.org/0000-0002-7165-8067)
- Andrew H.S. Lee (ORCID: https://orcid.org/0000-0003-2496-4050)
- Silvana Di Palma (ORCID: https://orcid.org/0000-0003-0155-1771)
- Yasmeen Mir
- P J Carder
- Sarah E. Pinder (ORCID: https://orcid.org/0000-0003-4167-8910)
- Purnima Makhija (ORCID: https://orcid.org/0000-0001-6664-1001)
Institutions
- University College Dublin (IE)
- Belfast Health and Social Care Trust (GB)
- Nottingham University Hospitals NHS Trust (GB)
- University of Nottingham (GB)
- University of Liverpool (GB)
- Royal Free London NHS Foundation Trust (GB)
- King's College London (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Barts Health NHS Trust (GB)
- Aintree University Hospitals NHS Foundation Trust (GB)
- Queen Elizabeth Hospital Birmingham (GB)
- St James's University Hospital (GB)
- St. Vincent's University Hospital (IE)
- Royal Surrey NHS Foundation Trust (GB)
- University Hospitals of Derby and Burton NHS Foundation Trust (GB)
- Wythenshawe Hospital (GB)
- Addenbrooke's Hospital (GB)
- Bradford Teaching Hospitals NHS Foundation Trust (GB)
- NIHR Cambridge Biomedical Research Centre (GB)
- University College London (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- Histopathology
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1111/his.15402
- Primary Topic
- Breast Lesions and Carcinomas
- Type
- article
- Field-Weighted Citation Impact
- 0.00