Genetic ablation of p16 mitigates premature osteoporosis induced by PTHrP nuclear localization sequence and C-terminal deletion through inhibition of cellular senescence
p16-mediated cellular senescence plays a crucial role in premature osteoporosis caused by PTHrP dysfunction. Targeting cellular senescence pathways may offer a promising therapeutic strategy for treating premature osteoporosis and age-related bone loss.
Authors
- Qi Xue
- Dengshun Miao (ORCID: https://orcid.org/0000-0002-2682-3502)
- Yongli Han (ORCID: https://orcid.org/0000-0001-9673-9181)
- Dong Zhan
- Wanxin Qiao
Institutions
- Nanjing Children's Hospital (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Changzhou Vocational Institute of Engineering (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Stem Cells
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1093/stmcls/sxae088
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00