Increased expression levels of PIEZO1 in visceral adipose tissue in obesity and type 2 diabetes are triggered by mechanical forces and are associated with inflammation
Static compression triggered an upregulation of PIEZO1 in VAT explants together with a strong inflammation. In addition, the increased expression of PIEZO1 in VAT in obesity and obesity-associated T2D, primarily attributable to adipocytes, is closely associated with SWELL1 and inflammatory markers.
Authors
- Victoria Catalán (ORCID: https://orcid.org/0000-0002-7513-7509)
- Gema Frühbeck (ORCID: https://orcid.org/0000-0002-8305-7154)
- Amaia Rodrı́guez (ORCID: https://orcid.org/0000-0002-2180-461X)
- Camilo Silva (ORCID: https://orcid.org/0000-0002-3466-1291)
- Beatriz Ramírez (ORCID: https://orcid.org/0000-0003-3381-7220)
- Sara Becerril (ORCID: https://orcid.org/0000-0002-3441-1970)
- Xabier Unamuno (ORCID: https://orcid.org/0000-0003-4260-1325)
- Ana Sancho (ORCID: https://orcid.org/0000-0002-0560-9187)
- Javier Gómez‐Ambrosi (ORCID: https://orcid.org/0000-0001-5601-1604)
- Jorge Baixauli (ORCID: https://orcid.org/0000-0002-0667-7827)
- Gabriel Reina (ORCID: https://orcid.org/0000-0003-4079-9753)
- Javier A. Cienfuegos (ORCID: https://orcid.org/0000-0002-6767-0573)
Institutions
- Instituto de Salud Carlos III (ES)
- Navarre Institute of Health Research (ES)
- Clinica Universidad de Navarra (ES)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1186/s10020-024-01008-1
- Citations
- 4
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 1.31
Funders
- Universidad de Navarra
- Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición
- Instituto de Salud Carlos III