Association of immunosuppressive CD45<sup>+</sup>CD33<sup>+</sup>CD14<sup>−</sup> CD10<sup>−</sup>HLA-DR<sup>−/low</sup> neutrophils with poor prognosis in patients with lymphoma and their expansion and activation through STAT3/arginase-1 pathway <i>
CD10<sup>-</sup> neutrophils exhibited basic characteristics similar to conventional myeloid-derived suppressor cells. Our observations provide a promising STAT3 or Arg-1 targeting strategy for B-NHL and an important method for generating remarkably amounts of inhibitory granulocyte populations rich in CD10<sup>-</sup> neutrophils for immunotherapy.
Authors
- Zhimin Zhai (ORCID: https://orcid.org/0000-0003-0950-8364)
- Ji Zhou (ORCID: https://orcid.org/0000-0002-1361-5421)
- Yangyang Ding (ORCID: https://orcid.org/0000-0003-1588-2571)
- Jinjing Guo
- Wanqiu Zhang
- Xue Liang (ORCID: https://orcid.org/0000-0002-4673-3707)
- Jinli Zhu
- Meng Xiao (ORCID: https://orcid.org/0000-0003-4761-7756)
- Huiping Wang (ORCID: https://orcid.org/0000-0003-1803-1801)
- Xunyi Jiao
Institutions
- Anhui Medical University (CN)
- Fuyang City People's Hospital (CN)
- Fuyang Maternity and Child Health Care Hospital (CN)
- Jining First People's Hospital (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- CytoJournal
- Published
- 2024-12-20
- DOI
- https://doi.org/10.25259/cytojournal_165_2024
- Citations
- 8
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.92
Funders
- National Natural Science Foundation of China