Bone morphogenetic proteins, <scp>DNA</scp> methylation, and gut microbiota interaction in lumbar disc degeneration: A multi‐omics Mendelian randomization study
This multi-omics study revealed that the BMP genes associated with LDD are regulated by DNA methylation. There are genetic differences between gut gene expression and the gut microbiota. These findings provide evidence for new therapeutic targets in the future.
Authors
- Shuaikang Wang (ORCID: https://orcid.org/0000-0001-5232-2456)
- Shibao Lu (ORCID: https://orcid.org/0000-0002-6508-4458)
- Dongfan Wang (ORCID: https://orcid.org/0000-0003-2869-3809)
- Xiaolong Chen (ORCID: https://orcid.org/0000-0003-2083-0549)
- Pengyun Wang (ORCID: https://orcid.org/0000-0001-8410-8390)
- Wei‐Guo Zhu (ORCID: https://orcid.org/0000-0001-8385-6581)
- Chao Kong (ORCID: https://orcid.org/0000-0001-7611-2648)
- Xiangyu Li (ORCID: https://orcid.org/0000-0002-5722-0018)
- Qijun Wang
- Yu Wang (ORCID: https://orcid.org/0000-0001-6351-6467)
- Wei Wang (ORCID: https://orcid.org/0000-0003-1568-222X)
Institutions
- Capital Medical University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Central Hospital of Zibo (CN)
Publication Details
- Journal
- JOR Spine
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/jsp2.70027
- Citations
- 1
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- Beijing Municipal Natural Science Foundation