Objective Measurement of Lisdexamfetamine’s Effects on Reading Patterns in Attention-Deficit Hyperactivity Disorder: A Case Report Utilizing Eye-Tracking Technology

This case report investigates the temporal dynamics of lisdexamfetamine (Vyvanse) in an adult individual with Attention-Deficit Hyperactivity Disorder (ADHD) through novel eye-tracking methodology.Using iFocus, a computer-based tool that quantifies reading patterns based on eye tracking, we tracked medication effects on reading behaviour throughout the day and compared these objective measurements with both the patient's baseline performance and subjective reports.Our findings revealed peak medication efficacy at 6 hours post-administration, with sustained elevated performance for an additional 3 hours.These results diverge from previous literature, which typically reports diminished evening effectiveness [1] and peak plasma concentrations at 4 hours post-administration according to pharmacokinetic studies [2].This study represents the first application of objective eye-tracking metrics to measure the temporal course of ADHD medication effects, providing a potential new paradigm for monitoring treatment response.The alignment between objective measurements and individual's-reported experiences suggests that eye-tracking technology may offer a valuable complement to existing methods of assessing medication efficacy in ADHD treatment.