Clinical and demographic factors modify the association between plasma phosphorylated tau‐181 and cognition
Greater plasma p-tau181 was associated with lower cognition across most domains.Associations between p-tau181 and cognition were modified by age and sex.Level of p-tau181 was more strongly associated with cognition in people with mild cognitive impairment (MCI) and apolipoprotein E (<i>APOE</i>) ε4.
Authors
- Marilyn Steinbach
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Logan C. Dumitrescu (ORCID: https://orcid.org/0000-0002-9782-9944)
- Amalia Jo Peterson (ORCID: https://orcid.org/0000-0002-7015-7957)
- Corey J. Bolton (ORCID: https://orcid.org/0000-0002-1715-5370)
- Omair A. Khan (ORCID: https://orcid.org/0000-0002-9259-9086)
- Angela Lee Jefferson (ORCID: https://orcid.org/0000-0002-8245-0587)
- Katherine A. Gifford (ORCID: https://orcid.org/0000-0001-6232-9408)
- Julia O’Malley
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0002-4671-6763)
- Dandan Liu (ORCID: https://orcid.org/0000-0002-1480-0290)
Institutions
- Sahlgrenska University Hospital (SE)
- UK Dementia Research Institute (GB)
- University College London (GB)
- University of Gothenburg (SE)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/dad2.70047
- Citations
- 3
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- U.S. Department of Defense
- Foundation for the National Institutes of Health
- Alzheimer's Association
- Familjen Erling-Perssons Stiftelse
- Northern California Institute for Research and Education
- Stiftelsen för Gamla Tjänarinnor
- EU Joint Programme – Neurodegenerative Disease Research
- National Institute for Health and Care Research
- University College London
- European Commission
- Hjärnfonden
- Vetenskapsrådet
- UK Dementia Research Institute
- National Institutes of Health
- HORIZON EUROPE Framework Programme
- Canadian Institutes of Health Research
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering