Multi-omics approaches reveal that diffuse midline gliomas present altered DNA replication and are susceptible to replication stress therapy
This whole genome multi-omics approach provides insights into the cell cycle regulation of DMG via the H3K27M mutations and establishes a pharmacologic vulnerability in DNA replication, which resolves a potentially novel therapeutic strategy for this non-curable disease.
Authors
- Mariella G. Filbin (ORCID: https://orcid.org/0000-0002-2613-8126)
- Ruslan I. Sadreyev (ORCID: https://orcid.org/0000-0002-4240-5466)
- Andreas Ettinger (ORCID: https://orcid.org/0000-0001-6436-010X)
- Kashish Chetal (ORCID: https://orcid.org/0000-0001-9314-5759)
- Adriana Gonzalez‐Sandoval
- Anastasia E. Hains (ORCID: https://orcid.org/0000-0002-0731-8818)
- Maria‐Elena Torres‐Padilla (ORCID: https://orcid.org/0000-0002-1020-2074)
- Carlos Alberto Oliveira de Biagi (ORCID: https://orcid.org/0000-0003-0700-3135)
- Tsunetoshi Nakatani (ORCID: https://orcid.org/0009-0006-0517-9638)
- Joana G. Marques (ORCID: https://orcid.org/0000-0001-7152-9655)
- Capucine Van Rechem (ORCID: https://orcid.org/0000-0002-5408-6124)
- Renjitha Pillai
Institutions
- Broad Institute (US)
- Harvard University (US)
- Helmholtz Zentrum München (DE)
- Massachusetts General Hospital (US)
- Stanford Medicine (US)
- Dana-Farber/Boston Children's Cancer and Blood Disorders Center (US)
- Stanford University (US)
Publication Details
- Journal
- Genome biology
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1186/s13059-024-03460-y
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00