Bone marrow mesenchymal stem cell exosomes suppress JAK/STAT signaling pathway in acute myeloid leukemia in vitro
Since JAK/STAT signaling contributes to AML survival, our findings suggest that the downregulation of JAK/STAT genes by BM-MSC exosomes in leukemic cells may aid in designing a potent therapeutic strategy for AML treatment.
Authors
- Mehdi Bakhtiyaridovvombaygi (ORCID: https://orcid.org/0000-0002-6861-3095)
- Sahar Jalilivand (ORCID: https://orcid.org/0009-0006-2769-5481)
- Maryam Nabigol
- Ahmad Gharehbaghian (ORCID: https://orcid.org/0000-0003-4265-585X)
Institutions
- Shahid Beheshti University of Medical Sciences (IR)
Publication Details
- Journal
- Blood Research
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1007/s44313-024-00051-5
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.47