Systemic lupus erythematosus and herpes zoster: Difficulties of curation (description of clinical observations)

Patients with systemic lupus erythematosus (SLE) have an increased risk of developing herpes zoster (HZ). Vaccination difficulties arise in these patients due to possible interactions with the therapy used with glucocorticoids, disease-modifying antirheumatic drugs and biologic disease-modifying anti-rheumatic drugs. The description of two clinical observations of patients with SLE, who developed severe HZ against the background of active SLE and therapy with immunosuppressive drugs, is given. The issue of the need for vaccination in Russia against varicella zoster virus of patients on immunosuppressive therapy is discussed.