Integrating single-cell RNA-Seq and machine learning to dissect tryptophan metabolism in ulcerative colitis
This study is the first to reveal the heterogeneity of tryptophan metabolism at the single-cell level in UC, with macrophages emerging as key contributors to inflammatory processes. The identification of CTSS, S100A11, and TUBB as key regulators of tryptophan metabolism in UC underscores their potential as biomarkers and therapeutic targets.
Authors
- Shiyu Du (ORCID: https://orcid.org/0000-0002-5482-2240)
- Jiali Yu (ORCID: https://orcid.org/0009-0002-2597-9609)
- Hongying Qi
- Yanli Zhang (ORCID: https://orcid.org/0000-0003-1481-6361)
- Fang Liu (ORCID: https://orcid.org/0000-0002-8325-1213)
- Li Jiang (ORCID: https://orcid.org/0000-0002-8530-4737)
- Guorong Chen
- Junhai Zhang (ORCID: https://orcid.org/0000-0002-3514-0471)
- Shijie Sun
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China-Japan Friendship Hospital (CN)
- Peking Union Medical College Hospital (CN)
- Aviation General Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1186/s12967-024-05934-w
- Citations
- 26
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 6.25