The inactivation of the Niemann Pick C1 cholesterol transporter restricts SARS-CoV-2 entry into host cells by decreasing ACE2 abundance at the plasma membrane
Overall, this study provides compelling evidence that the inhibition of NPC1 cholesterol transporter activity generates a cellular environment that hinders SARS-CoV-2 entry. ACE2 depletion from the plasma membrane appears to play a major role as limiting factor for viral entry.
Authors
- Jessica Tiberi
- Piergiorgio La Rosa (ORCID: https://orcid.org/0000-0002-9723-2363)
- John Hiscott (ORCID: https://orcid.org/0000-0003-2076-6321)
- Sonia Canterini (ORCID: https://orcid.org/0000-0003-0911-7873)
- Sofia Maria Luigia Tiano
- Enrico Palermo (ORCID: https://orcid.org/0000-0002-9595-6931)
- Mirko Cortese (ORCID: https://orcid.org/0000-0003-1786-4211)
- Maria Teresa Fiorenza (ORCID: https://orcid.org/0000-0002-5079-4019)
- Roberta Stefanelli (ORCID: https://orcid.org/0000-0002-7782-7757)
Institutions
- University of Campania "Luigi Vanvitelli" (IT)
- European Brain Research Institute (IT)
- Fondazione Santa Lucia (IT)
- Telethon Institute Of Genetics And Medicine (IT)
- Istituto Pasteur (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1186/s13578-024-01331-4
- Citations
- 3
- Primary Topic
- Calcium signaling and nucleotide metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.21
Funders
- Fondazione Telethon
- Sapienza Università di Roma