C3+ cancer-associated fibroblasts promote tumor growth and therapeutic resistance in gastric cancer via activation of the NF-κB signaling pathway
The study suggests that NF-κB pathway-mediated CAF activation enhances C3 secretion, driving EMT, migration, chemoresistance, and immune evasion in GC progression. Targeting the NF-κB/C3 signaling axis in CAFs may offer a viable therapeutic strategy for GC management.
Authors
- Zhenxiong Zhao (ORCID: https://orcid.org/0000-0003-4428-8547)
- Yakai Huang
- Yingjing Zhang (ORCID: https://orcid.org/0000-0002-5584-7925)
- Ergang Guo
- Xiong Si
- Jianpeng Gao (ORCID: https://orcid.org/0000-0002-0743-8115)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Chinese Academy of Sciences (CN)
- Fudan University Shanghai Cancer Center (CN)
- Zhejiang Cancer Hospital (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1186/s12967-024-05939-5
- Citations
- 10
- Primary Topic
- Cancer Mechanisms and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 4.25
Funders
- National Natural Science Foundation of China