Conjugated bile acids alleviate acute pancreatitis through inhibition of TGR5 and NLRP3 mediated inflammation
Conjugated bile acids significantly inhibit NLRP3 inflammasome activation by activating TGR5 pathway, thereby alleviating pancreatic immunopathology. The results provide new insights into the variability of clinical outcomes and paves the way for developing more effective therapeutic interventions for AP.
Authors
- Shu Zhu (ORCID: https://orcid.org/0000-0003-2919-5473)
- Jinyan Xie (ORCID: https://orcid.org/0000-0002-5406-4195)
- Jingtianyi Liu
- Xiuliu Guo
- Guo Feng (ORCID: https://orcid.org/0000-0002-8003-8345)
- Ziyi Zhang (ORCID: https://orcid.org/0000-0002-2175-4931)
- Yijie Gu (ORCID: https://orcid.org/0000-0002-6607-2125)
- Xin-Quan Ji
Institutions
- Sir Run Run Shaw Hospital (CN)
- Institute of Microbiology (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1186/s12967-024-05922-0
- Citations
- 13
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 7.45
Funders
- Sir Run Run Shaw Hospital
- Zhejiang Traditional Chinese Medicine Administration
- Natural Science Foundation of Zhejiang Province
- Science and Technology Program of Zhejiang Province