ABL1‒YAP1 axis in intestinal stem cell activated by deoxycholic acid contributes to hepatic steatosis
Our findings reveal that the activation of the ABL1‒YAP1 axis in ISCs by DCA contributes to hepatic steatosis through the gut‒liver axis, which may provide a potential intestinal therapeutic target for MAFLD.
Authors
- Xiaowan Wu (ORCID: https://orcid.org/0000-0001-6572-1464)
- Tiancheng Mao
- Lungen Lu (ORCID: https://orcid.org/0000-0002-1533-4068)
- Leheng Liu (ORCID: https://orcid.org/0000-0002-7046-9205)
- Wenlu Niu
- Hui Zhou (ORCID: https://orcid.org/0000-0002-2565-8584)
- Xiaobo Cai (ORCID: https://orcid.org/0000-0001-7697-5873)
- Dongrui You
- Yulun Wu (ORCID: https://orcid.org/0009-0001-4210-9675)
- Xianjun Xu
Institutions
- University of Science and Technology of China (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1186/s12967-024-05865-6
- Citations
- 5
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences