Microbial and proteomic signatures of type 2 diabetes in an Arab population
This is the first study to assess the salivary microbiota in T2D patients from a large cohort of the Qatari population. We found significant differences in the salivary microbiota of pre-diabetic and diabetic individuals compared to non-diabetic controls. Our study is also the first to assess the salivary proteome using SOMAScan in diabetic and non-diabetic subjects. Integration of the microbiota and proteome profiles revealed a unique signature for T2D that can be used as potential T2D biomarkers.
Authors
- Jean‐Charles Grivel (ORCID: https://orcid.org/0000-0003-0365-3181)
- Selvasankar Murugesan (ORCID: https://orcid.org/0000-0001-8386-6536)
- Mohamed Nadhir Djekidel (ORCID: https://orcid.org/0000-0001-5361-1858)
- Souhaila Al Khodor (ORCID: https://orcid.org/0000-0003-4858-7130)
- Ghada Yousif (ORCID: https://orcid.org/0000-0002-5867-1937)
- Giusy Gentilcore (ORCID: https://orcid.org/0000-0003-3546-8642)
Institutions
- Qatar Airways (Qatar) (QA)
- Sidra Medical and Research Center (QA)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1186/s12967-024-05928-8
- Citations
- 3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Sidra Medicine
- Fonds National de la Recherche Luxembourg
- Qatar National Research Fund