TET3-facilitated differentiation of human umbilical cord mesenchymal stem cells into oligodendrocyte precursor cells for spinal cord injury recovery
Our study demonstrated that TET3-mediated demethylation reshapes the methylation patterns of HUCMSCs, enabling their efficient one-step conversion into OPCs and significantly reducing the time required for cell preparation. This approach offers a potential strategy for early intervention in SCI. In an SCI model, TET3-induced OPCs contributed to spinal cord repair, providing novel insights into cell therapy strategies for SCI through the lens of methylation regulation.
Authors
- Tianli Wei
- Mi Li
- Jingsong Liu (ORCID: https://orcid.org/0009-0003-5607-1836)
- Pengfei Li (ORCID: https://orcid.org/0000-0003-1334-8770)
- Yangyang Wang (ORCID: https://orcid.org/0000-0003-0374-4147)
- Yubo Zhang (ORCID: https://orcid.org/0000-0002-7762-0027)
- Yansong Wang (ORCID: https://orcid.org/0000-0002-3688-320X)
- Yishu Liu (ORCID: https://orcid.org/0009-0004-4911-8939)
- Man Guo (ORCID: https://orcid.org/0000-0001-9497-5279)
- Zhibin Peng
- Yingwei Zhao
Institutions
- Harbin Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1186/s12967-024-05929-7
- Citations
- 6
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Heilongjiang Province
- Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions