Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma
This study maps the immune response in FT precursors of HGSOC, highlighting localized IFN signaling, chromosomal instability, and competing immune surveillance and suppression along the progression axis. It provides an explorable public spatial profiling atlas for investigating precancer mechanisms, biomarkers, and early detection and interception strategies. See related commentary by Recouvreux and Orsulic, p. 1093.
Authors
- Ritika Kundra (ORCID: https://orcid.org/0000-0001-6723-2859)
- Judith Agudo (ORCID: https://orcid.org/0000-0002-3576-3169)
- Gabriel Mingo (ORCID: https://orcid.org/0000-0002-7593-5885)
- Jeremy L. Muhlich (ORCID: https://orcid.org/0000-0002-0811-637X)
- Sandro Santagata (ORCID: https://orcid.org/0000-0002-7528-9668)
- Dalia K. Omran (ORCID: https://orcid.org/0000-0003-4323-2621)
- Tanjina Kader (ORCID: https://orcid.org/0000-0002-1463-7593)
- Charles W. Drescher (ORCID: https://orcid.org/0000-0002-6579-0416)
- Roxanne J. Pelletier (ORCID: https://orcid.org/0000-0002-1957-5483)
- James R. Heath (ORCID: https://orcid.org/0000-0001-5356-4385)
- Nikolaus Schultz (ORCID: https://orcid.org/0000-0002-0131-4904)
- Baby A. Satravada (ORCID: https://orcid.org/0000-0001-6608-345X)
- Clarence Yapp (ORCID: https://orcid.org/0000-0003-1144-5710)
- Clemens B. Hug (ORCID: https://orcid.org/0000-0002-8299-3274)
- Natalie N. C. Shih (ORCID: https://orcid.org/0009-0007-5025-1026)
- Jia‐Ren Lin (ORCID: https://orcid.org/0000-0003-4702-7705)
- Jong Suk Lee (ORCID: https://orcid.org/0009-0008-4460-7118)
- Peter Karl Sorger (ORCID: https://orcid.org/0000-0002-3364-1838)
- Ronny Drapkin (ORCID: https://orcid.org/0000-0002-6912-6977)
- Mariana Lopez Leon (ORCID: https://orcid.org/0000-0002-4599-7719)
- Ino de Bruijn (ORCID: https://orcid.org/0000-0001-5427-4750)
- Euihye Jung (ORCID: https://orcid.org/0000-0003-1202-247X)
- Yu‐An Chen (ORCID: https://orcid.org/0000-0001-7228-4696)
- Shannon Coy (ORCID: https://orcid.org/0000-0003-0033-9031)
- Juliann B. Tefft (ORCID: https://orcid.org/0000-0002-8826-665X)
- Sabrina Chan (ORCID: https://orcid.org/0000-0002-4557-2972)
- Stefan Gysler (ORCID: https://orcid.org/0000-0001-6188-8523)
- Sarah H. Kim (ORCID: https://orcid.org/0000-0003-1381-6781)
- Yilin Xu (ORCID: https://orcid.org/0009-0002-5696-7475)
Institutions
- Gynecologic Oncology Group (US)
- Brigham and Women's Hospital (US)
- Memorial Sloan Kettering Cancer Center (US)
- Harvard University (US)
- University of Washington (US)
- Harvard University Press (US)
- Institute for Systems Biology (US)
- Kettering University (US)
- Fred Hutch Cancer Center (US)
- Dana-Farber Cancer Institute (US)
- Center for Systems Biology (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-1366
- Citations
- 32
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 17.19