THROMBOCYTOPENIA AND C-REACTIVE PROTEIN AS MARKERS OF HEMORRHAGIC FEVER WITH RENAL SYNDROME, COMPLICATED BY ACUTE KIDNEY FAILURE

Introduction. Hemorrhagic fever with renal syndrome is a common zoonotic disease that can lead to acute kidney failure in severe cases. Although there has been a lot of research on clinical and laboratory indicators, there are no specific markers to identify cases of hemorrhagic fever with renal syndrome, complicated by acute kidney failure. This study aims to examine platelet production and inflammatory factors in laboratory tests as potential markers for identifying this complication. Materials and Methods. 135 patients were examined. The group with mild to moderate disease consisted of 62 individuals, and the group with severe disease without acute kidney failure included 73 individuals. Blood tests, including complete blood count and biochemical analysis, were performed on all patients. Clinical and laboratory data were used to establish the diagnosis in accordance with clinical recommendations. The following parameters were studied: Leukocytes, erythrocytes, hemoglobin, platelets, prothrombin time, C-reactive protein, total protein, serum creatinine, blood urea nitrogen, glucose, and potassium ions. Parametric statistical methods were used. Results and Discussion. Substantial changes were found in most parameters analyzed at all severity levels of hemorrhagic fever. Platelet levels below 60 x 109/L, as well as significantly increased C-reactive protein levels exceeding 30 mg/L, preceded the development of acute kidney failure. Conclusions. Thrombocytopenia and high C-reactive protein levels may be considered the early signs of hemorrhagic fever complicated by acute kidney failure.