Activity‐Based Proteome Profiling of Serum Serine Hydrolases: Application in Pediatric Abusive Head Trauma
To our knowledge, this is the first study to investigate the ABPP of the SHs enzyme family to detect changes in their physiological activity in blood serum in severe TBI. We used antemortem (AM) serum from infants under the age of 2 years who were victims of AHT with a severe form of ICH. The analytical approach used in the proof-of-principle study shows reduced activities of serum serine lipases in AHT cases and could be further investigated in mild forms of AHT, which currently show 30% of misdiagnosed cases in clinics.
Authors
- Marc Augsburger (ORCID: https://orcid.org/0000-0002-5606-3831)
- Aurélien Thomas (ORCID: https://orcid.org/0000-0001-6790-2285)
- Estelle Maret
- Tony Fracasso (ORCID: https://orcid.org/0000-0002-5455-2084)
- Tatjana Sajic (ORCID: https://orcid.org/0000-0003-4282-1336)
- Federica Gilardi (ORCID: https://orcid.org/0000-0001-5421-2779)
- Kim Wiskott (ORCID: https://orcid.org/0000-0002-2974-6979)
- Tobias Shipley
Institutions
- University Centre of Legal Medicine (CH)
- University of Lausanne (CH)
Publication Details
- Journal
- PROTEOMICS - CLINICAL APPLICATIONS
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1002/prca.202400022
- Citations
- 2
- Primary Topic
- Child Abuse and Related Trauma
- Type
- article
- Field-Weighted Citation Impact
- 2.22