Impact of c-JUN deficiency on thalamus development in mice and human neural models
Our findings from in vivo and in vitro experiments indicate that c-JUN depletion impedes the extension of nerve fibers and renders the thalamus susceptible to dysplasia during early mouse embryonic development and human ThO patterning. Our work provides evidence for the first time that c-JUN is a key transcription regulator that play important roles in the thalamus/diencephalon development.
Authors
- Jiaming Lai (ORCID: https://orcid.org/0000-0001-7028-9979)
- Huanxing Su (ORCID: https://orcid.org/0000-0003-3254-825X)
- Jiantao Shi (ORCID: https://orcid.org/0000-0002-0039-8800)
- M.A. Mazid (ORCID: https://orcid.org/0000-0003-2190-2591)
- Dajiang Qin (ORCID: https://orcid.org/0009-0008-2792-3514)
- Jieying Zhu
- Qing Chen (ORCID: https://orcid.org/0000-0002-2088-0370)
- Dongwei Li (ORCID: https://orcid.org/0000-0001-7777-4045)
- Ran Zhang (ORCID: https://orcid.org/0000-0003-3376-6945)
Institutions
- Xinjiang Medical University (CN)
- Chinese University of Hong Kong (HK)
- Chinese Academy of Sciences (CN)
- University of Macau (MO)
- Fifth Affiliated Hospital of Xinjiang Medical University (CN)
- Guangzhou Institutes of Biomedicine and Health (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou Regenerative Medicine and Health Guangdong Laboratory (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1186/s13578-024-01303-8
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese Academy of Sciences
- Science, Technology and Innovation Commission of Shenzhen Municipality