Identification of D842V mutation in gastrointestinal stromal tumors based on CT radiomics: a multi-center study
This study demonstrated the potential of radiomics features based on venous-phase CECT images to identify D842V mutation in GISTs. Our model may provide an alternative approach to guide TKI therapy for patients inaccessible to sequence variant testing, potentially improving treatment outcomes for GIST patients especially in resource-limited settings.
Authors
- Ranying Zhang (ORCID: https://orcid.org/0000-0002-0243-6102)
- Yuxuan Zhao (ORCID: https://orcid.org/0000-0001-7912-6332)
- Yan Zhou (ORCID: https://orcid.org/0000-0003-2661-4011)
- Dexin Yu (ORCID: https://orcid.org/0000-0001-7462-3153)
- Shiteng Suo (ORCID: https://orcid.org/0000-0003-2528-2836)
- Xiaobo Li (ORCID: https://orcid.org/0000-0003-2554-4234)
- Wang Zhang (ORCID: https://orcid.org/0000-0002-8636-2816)
- Jiang Lin (ORCID: https://orcid.org/0000-0002-4704-9157)
- Qingwei Zhang (ORCID: https://orcid.org/0000-0001-6908-049X)
- Zhenhui Xie
- Yang Song
Institutions
- Shanghai Medical College of Fudan University (CN)
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Zhongshan Hospital (CN)
- Qilu Hospital of Shandong University (CN)
- Siemens (China) (CN)
Publication Details
- Journal
- Cancer Imaging
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1186/s40644-024-00815-3
- Primary Topic
- Gastrointestinal Tumor Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Renji Hospital