Association between GRIN2B polymorphism and Parkinson’s disease risk, age at onset, and progression in Southern China
The GRIN2B rs219882 G allele is associated with increased PD susceptibility, particularly in LOPD. The carriers of the GG + GT genotype exhibited more rapid motor symptom progression, with a pronounced impact on rigidity and axial impairment.
Authors
- Huan Song (ORCID: https://orcid.org/0000-0001-5806-0928)
- Hongxia Li (ORCID: https://orcid.org/0000-0001-5940-2264)
- Bei Zhang (ORCID: https://orcid.org/0000-0002-7797-7616)
- Hongxiang Yu (ORCID: https://orcid.org/0000-0003-0066-1223)
- C. X. Cui (ORCID: https://orcid.org/0000-0002-9811-342X)
- Yingying Han (ORCID: https://orcid.org/0000-0002-4908-0828)
- Yiwen Bao (ORCID: https://orcid.org/0000-0001-9255-856X)
Institutions
- Fudan University (CN)
- Shanghai East Hospital (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2024-12-20
- DOI
- https://doi.org/10.3389/fneur.2024.1459576
- Citations
- 2
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.74
Funders
- National Natural Science Foundation of China