Neoadjuvant chemotherapy by liposomal doxorubicin boosts immune protection of tumor membrane antigens-based nanovaccine
Autologous tumor cell membrane antigen-based vaccines (TMVs) have garnered extensive attention as personalized immunotherapy. However, patients who take TMVs therapy usually undergo various treatments prior to surgery, and these processes modulate the immunogenicity of the tumor membrane and the tumor immune microenvironment. Herein, we investigate the impact of preoperative chemotherapy on the efficacy of TMVs. Liposomal doxorubicin ameliorates the immunosuppressive tumor microenvironment and enhances immunological molecule expression on the tumor membrane. This has driven TMVs to elicit a more robust immune response than doxorubicin, resulting in more effective immune protection. The TMVs formulated from liposomal doxorubicin-treated tumors induce superior dendritic cell maturation and T cell activation compared to doxorubicin, thus demonstrating better efficacy in preventing recurrence and metastasis in the postoperative murine model. Collectively, our study suggests that chemotherapy can induce immunomodulatory changes that augment the therapeutic potential of immunotherapy and provides valuable insights into the clinical utilization of TMVs.
Authors
- Ruifang Zhao (ORCID: https://orcid.org/0000-0002-2735-2159)
- Yaohua Wei (ORCID: https://orcid.org/0000-0001-9388-2900)
- Ronghui Deng (ORCID: https://orcid.org/0000-0003-1282-8289)
- Jian Shi (ORCID: https://orcid.org/0000-0002-0481-3442)
- Guangjun Nie (ORCID: https://orcid.org/0000-0001-5040-9793)
- Guoguang Zheng (ORCID: https://orcid.org/0000-0002-0829-3501)
- Tianyu Ma (ORCID: https://orcid.org/0000-0002-2326-5760)
- Chuanxi Xiong (ORCID: https://orcid.org/0000-0003-0878-0884)
- Nan Li (ORCID: https://orcid.org/0000-0002-7529-0781)
- Yang Chen (ORCID: https://orcid.org/0000-0001-7661-5923)
- Rong Li (ORCID: https://orcid.org/0000-0003-0305-5579)
- Hanqing Chen (ORCID: https://orcid.org/0000-0001-5442-2071)
- Hao Ding (ORCID: https://orcid.org/0000-0003-0774-4670)
- Yuliang Zhao (ORCID: https://orcid.org/0000-0002-9586-9360)
- Hao Qin (ORCID: https://orcid.org/0000-0002-6858-7595)
- Yixuan Lin (ORCID: https://orcid.org/0000-0003-2693-0559)
- Yuanyuan Lv (ORCID: https://orcid.org/0000-0003-4736-3733)
Institutions
- Capital Medical University (CN)
- National Center for Nanoscience and Technology (CN)
Publication Details
- Journal
- Cell Reports Medicine
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1016/j.xcrm.2024.101877
- Citations
- 13
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 3.13
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Ministry of Science and Technology of the People's Republic of China
- Beijing Municipal Science and Technology Commission
- Beijing Nova Program
- National Key Research and Development Program of China