Age-related lung changes linked to altered lysosomal protease profile, histology, and ultrastructure
The findings indicate an age-related upregulation of cathepsins G and X along with heightened MMP activity in old rat lung tissues, potentially contributing to the degradation of fibronectin within the ECM. These alterations highlight potential mechanisms underlying age-associated changes in lung tissue integrity and provide insights into protease-mediated ECM remodeling in the context of aging lungs.
Authors
- Akram A. Alfuraydi
- Ali Hakamy (ORCID: https://orcid.org/0000-0001-9318-1784)
- Mohammed Aufy (ORCID: https://orcid.org/0000-0002-6693-4530)
- Ahmed M. Hussein (ORCID: https://orcid.org/0000-0002-7315-9886)
- Ayman Amer (ORCID: https://orcid.org/0000-0003-2583-3570)
- Mahmoud Abd‐Elkareem (ORCID: https://orcid.org/0000-0003-3715-011X)
- Mostafa A. Abdel-Maksoud (ORCID: https://orcid.org/0000-0002-6964-4846)
- Jana Lubec (ORCID: https://orcid.org/0000-0003-0657-7647)
- Mohamed H. Kotob (ORCID: https://orcid.org/0000-0003-4183-5517)
- Christian Studenik (ORCID: https://orcid.org/0000-0002-0910-4573)
- Veronika Barešová (ORCID: https://orcid.org/0000-0001-8989-6090)
- Mahmoud Ashry (ORCID: https://orcid.org/0000-0003-1993-7349)
- Medina Mustafic
Institutions
- University of Vienna (AT)
- Al-Azhar University (EG)
- Charles University (CZ)
- Paracelsus Medical University (AT)
- King Saud University (SA)
- King Faisal University (SA)
- Assiut University (EG)
- Jazan University (SA)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1371/journal.pone.0311760
- Citations
- 2
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- King Saud University