Lung immune incompetency after mild peritoneal sepsis and its partial restoration by type 1 interferon: a mouse model study
Histologically accelerated inflammation and paradoxically suppressed immunological regulator signaling were observed in the early recovery phase of sepsis. This observation may provide a model for the immunologically irresponsive state that occurs in some patients with sepsis. Systemic IFN-β partly restored the post-septic immunocompromised state, indicating its therapeutic potential for the immunosuppressive state seen in some patients with sepsis/ARDS.
Authors
- Takahiro Hiruma
- Qianling Meng
- Bruce C. Trapnell (ORCID: https://orcid.org/0000-0003-2817-6254)
- Michiko Ushio
- Tokie Totsu
- Masahiko Bougaki (ORCID: https://orcid.org/0000-0002-9716-5308)
- Kanji Uchida (ORCID: https://orcid.org/0000-0001-9337-1916)
- Fumiko Seto
- Tomoyuki Miyashita (ORCID: https://orcid.org/0009-0007-0436-5073)
- S.Y. Wu (ORCID: https://orcid.org/0000-0003-1189-2932)
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Fukushima Medical University (JP)
- University of Tokyo Hospital (JP)
- Southern Tohoku General Hospital (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Intensive Care Medicine Experimental
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1186/s40635-024-00707-7
- Citations
- 1
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- Japan Society for the Promotion of Science
- National Heart, Lung, and Blood Institute
- NHLBI Division of Intramural Research