Tin prefiltration in computed tomography does not significantly alter radiation-induced gene expression and DNA double-strand break formation
The current ex-vivo study indicates no changes regarding transcriptional and post-transcriptional DGE and DNA DSB induction when using the tin prefilter technique and even a significant tendency to lower radiation-induced DGE-changes due to the dose reduction of the tin prefilter with equal image quality compared to classical CT scan protocols was found.
Authors
- Simone Schüle (ORCID: https://orcid.org/0000-0003-3430-4822)
- Samantha Stewart (ORCID: https://orcid.org/0009-0009-9534-4028)
- Matthias Port (ORCID: https://orcid.org/0000-0002-8496-5883)
- Michael Abend (ORCID: https://orcid.org/0000-0001-5092-6280)
- Meinrad Beer (ORCID: https://orcid.org/0000-0001-7523-1979)
- Harry Scherthan
- Carsten Hackenbroch (ORCID: https://orcid.org/0000-0002-7736-8458)
- Patrick Ostheim (ORCID: https://orcid.org/0000-0002-8789-5470)
- Razan Muhtadi
- Cornelius Hermann
Institutions
- Universität Ulm (DE)
- University Hospital Regensburg (DE)
- Universität der Bundeswehr München (DE)
- University Hospital Ulm (DE)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1371/journal.pone.0315808
- Citations
- 1
- Primary Topic
- Radiation Dose and Imaging
- Type
- article
- Field-Weighted Citation Impact
- 0.40