Mycotic aneurysm due to Magnusiomyces capitatus complicating a second liver transplant in a colonized patient

This report presents an extremely rare case of a fungal mycotic aneurysm due to Magnusiomyces capitatus in a 51-year-old woman who is immunocompromised. The diagnosis was based on multiple computed tomography scans and the identification of the pathogen via sequencing of the internal transcribed spacer region. Long-term treatment with caspofungin for previous candidemia likely promoted the dissemination of this intrinsically echinocandin-resistant fungus from colonization sites in the lungs and rectal area. Long-term suppressive antifungal therapy with voriconazole and subsequently with posaconazole, combined with multiple surgical procedures, led to an improvement in the patient's condition. This case highlights the importance of considering a patient's comprehensive microbiological history and reassessing antimicrobial therapy in cases of nonimprovement or relapse.

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Publication Details

Journal
International Journal of Infectious Diseases
Published
2024-12-20
DOI
https://doi.org/10.1016/j.ijid.2024.107370
Citations
2
Primary Topic
Antifungal resistance and susceptibility
Type
article
Field-Weighted Citation Impact
0.78
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article

Mycotic aneurysm due to Magnusiomyces capitatus complicating a second liver transplant in a colonized patient

Matthieu Arsicot, Pauline Tirard-Collet, Charles Gibert, Jean Ménotti et al.
2 citations
International Journal of Infectious Diseases
Antifungal resistance and susceptibility
0.78
article

Mycotic aneurysm due to Magnusiomyces capitatus complicating a second liver transplant in a colonized patient

Matthieu Arsicot, Pauline Tirard-Collet, Charles Gibert, Jean Ménotti, Ugo Huvelle, Charline Miossec, Florence Persat, Florent Valour, Marie Wan, Thomas Penhoat, Yatrika Koumar
article en
2 citations

Abstract

This report presents an extremely rare case of a fungal mycotic aneurysm due to Magnusiomyces capitatus in a 51-year-old woman who is immunocompromised. The diagnosis was based on multiple computed tomography scans and the identification of the pathogen via sequencing of the internal transcribed spacer region. Long-term treatment with caspofungin for previous candidemia likely promoted the dissemination of this intrinsically echinocandin-resistant fungus from colonization sites in the lungs and rectal area. Long-term suppressive antifungal therapy with voriconazole and subsequently with posaconazole, combined with multiple surgical procedures, led to an improvement in the patient's condition. This case highlights the importance of considering a patient's comprehensive microbiological history and reassessing antimicrobial therapy in cases of nonimprovement or relapse.

International Journal of Infectious DiseasesVol. 151
Université Claude Bernard Lyon 1 (FR), École Normale Supérieure de Lyon (FR), Centre National de la Recherche Scientifique (FR), Inserm (FR), Centre Hospitalier Universitaire de La Réunion (RE), Hospices Civils de Lyon (FR), Société Française de Médecine Vasculaire (FR), Centre International de Recherche en Infectiologie (FR)
Good health and well-being
Openalex Percentile: Top 26%
Antifungal resistance and susceptibility
0.78
DOIOpen Access PDFOpenAlex
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Mycotic aneurysm due to Magnusiomyces capitatus complicating a second liver transplant in a colonized patient — Matthieu Arsicot, Pauline Tirard-Collet, et al. · International Journal of Infectious Diseases (2024) | TGRS Research Map | TGRS