Absence of gut microbiota alleviates iron overload-induced colitis by modulating ferroptosis in mice
Iron overload activates ferroptosis in colonic cells, increases the relative abundance of harmful bacteria, and exacerbates DSS-induced colitis in mice. Iron overload exacerbates DSS-induced ferroptosis and colitis in a microbiota-dependent manner. Targeting gut microbiota may offer new strategies for managing iron overload-induced colitis.
Authors
- Junzhou Chen (ORCID: https://orcid.org/0000-0002-3388-3503)
- Quyuan Wang (ORCID: https://orcid.org/0000-0002-5581-5317)
- Junqiu Luo (ORCID: https://orcid.org/0000-0002-1024-1866)
- Aimin Wu (ORCID: https://orcid.org/0000-0002-8582-4599)
- Ping Zheng (ORCID: https://orcid.org/0000-0003-0402-5507)
- Junning Pu
- Hui Yan (ORCID: https://orcid.org/0000-0001-7476-3914)
- Yuheng Luo (ORCID: https://orcid.org/0000-0003-4241-8053)
- Bing Yu (ORCID: https://orcid.org/0000-0001-6605-6742)
- Huifen Wang
- Chen Liu (ORCID: https://orcid.org/0000-0001-5974-1637)
- Jun He (ORCID: https://orcid.org/0000-0002-3170-7012)
- Xin Lai (ORCID: https://orcid.org/0000-0001-8006-0617)
- Daiwen Chen
- Ke Gu
Institutions
- Sichuan Agricultural University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1016/j.jare.2024.12.030
- Citations
- 10
- Primary Topic
- Iron Metabolism and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.54
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Sichuan Province