CORRECTION WITH POLYPHENOL PC-7 ON CHANGES IN COGNITIVE STATES AND CALCIUM DYNAMICS IN BRAIN SYNAPTOSOMES IN RATS UNDER CONDITIONS OF MODELED ALZHEIMER'S DISEASE IN VIVO

Alzheimer's disease (AD) is one of the most common manifestations of neurodegenerative dementia, characterized by changes in brain tissue long before the appearance of the first clinical symptoms. Animal models induced by AD are the cornerstone of any drug development program and offer the opportunity to make a significant and meaningful contribution to successful therapeutic development. We conducted experiments to determine whether this polyphenol crosses the blood-brain barrier by administering in vivo the polyphenol PC-7, which has a good effect on infection of these disease models, in a liposomal form based on soy phospholipids, in different ways. rats. In our experiments, when studying the behavior of rats modeled by AD, the behavior of rats initially selected in the tests "Open field", "Conditioned reflexes of passive escape" and "Conditioned reflexes of active escape" was studied. McGraw scale. It was found that the used polyphenol PС-7 has a positive effect on changes in cognitive states and the level of synaptosomal calcium that occur in AD states.