Transcranial Cortex-Wide Imaging of Murine Ischemic Perfusion With Large-Field Multifocal Illumination Microscopy
A high-speed fluorescence-based angiography method for transcranial stroke imaging in mice is introduced, which is capable of localizing brain perfusion changes and accurately assessing the ischemic penumbra. Compared with the whole-brain x-ray computed tomography and magnetic resonance imaging methods, which are conventionally used for stroke diagnosis and therapeutic monitoring, the new approach is simple and cost-effective, further offering high resolution and speed for in vivo studies. It thus opens new venues for brain perfusion research under various disease conditions such as stroke, neurodegeneration, or epileptic seizures.
Authors
- Irmak Gezginer (ORCID: https://orcid.org/0009-0002-4720-9680)
- Matthias T. Wyss (ORCID: https://orcid.org/0000-0002-2037-3424)
- Jeanne Droux (ORCID: https://orcid.org/0009-0008-7711-6673)
- Bruno Weber (ORCID: https://orcid.org/0000-0002-9089-0689)
- Hikari A. I. Yoshihara (ORCID: https://orcid.org/0000-0002-3274-7147)
- Mohamad El Amki (ORCID: https://orcid.org/0000-0003-1245-5283)
- Zhenyue Chen (ORCID: https://orcid.org/0000-0001-9508-7521)
- Quanyu Zhou (ORCID: https://orcid.org/0000-0001-7719-4649)
- Diana Kindler
- Chaim Glück (ORCID: https://orcid.org/0000-0002-8754-9965)
- Daniel Razansky (ORCID: https://orcid.org/0000-0001-8676-0964)
- Susanne Wegener (ORCID: https://orcid.org/0000-0003-4369-7023)
- Yu‐Hang Liu (ORCID: https://orcid.org/0000-0003-0629-3150)
Institutions
- Tongji University (CN)
- Institute for Biomedical Engineering (CH)
- World Wide Fund for Nature (CH)
- University Hospital of Zurich (CH)
- Institute of Pharmacology (CZ)
Publication Details
- Journal
- Stroke
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1161/strokeaha.124.047996
- Citations
- 7
- Primary Topic
- Photoacoustic and Ultrasonic Imaging
- Type
- article
- Field-Weighted Citation Impact
- 1.29