Effectiveness of tofacitinib versus tumor necrosis factor inhibitors and in those receiving tofacitinib as different lines of therapy in patients with rheumatoid arthritis: results from the United States CorEvitas Rheumatoid Arthritis Registry
NCT01402661 (ClinicalTrials.gov; July 25, 2011). Key Points • Using data from the US CorEvitas rheumatoid arthritis (RA) Registry, this study compared the effectiveness of tofacitinib versus tumor necrosis factor inhibitors (TNFi) and across tofacitinib lines of therapy. • Effectiveness of tofacitinib was similar to TNFi regimens up to month 12, while differences in some effectiveness outcomes at month 12 were observed with tofacitinib across different lines of therapy. • The findings of this study may inform future treatment decision-making in patients with RA.
Authors
- Janet Pope (ORCID: https://orcid.org/0000-0003-1479-5302)
- Carla Roberts‐Toler (ORCID: https://orcid.org/0000-0002-7347-7243)
- Page C. Moore (ORCID: https://orcid.org/0000-0002-3428-8781)
- Karim Richard Masri (ORCID: https://orcid.org/0000-0002-2178-9747)
- Miao Yu (ORCID: https://orcid.org/0000-0002-2804-6014)
- Leslie R. Harrold (ORCID: https://orcid.org/0000-0002-0170-2747)
- Jacqueline O’Brien (ORCID: https://orcid.org/0009-0002-4998-5747)
- Ahmed Shelbaya (ORCID: https://orcid.org/0000-0003-1028-5866)
- Clifton O. Bingham (ORCID: https://orcid.org/0000-0002-4752-5029)
- L. Sweet
Institutions
- Western University (CA)
- Johns Hopkins University (US)
- University of Massachusetts Chan Medical School (US)
- Pfizer (United States) (US)
- Johns Hopkins Medicine (US)
- Navitas Systems (United States) (US)
Publication Details
- Journal
- Clinical Rheumatology
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1007/s10067-024-07245-3
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Amgen
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- GlaxoSmithKline
- Ortho Dermatologics
- LEO Pharma
- Genentech
- Chugai Pharmaceutical