LAPTM4B enhances the stemness of CD133+ liver cancer stem-like cells via WNT/β-catenin signaling
LAPTM4B contributes significantly to CD133<sup>+</sup> CSLC stemness and inhibits β-catenin phosphorylation and ubiquitination degradation, activating WNT/β-catenin signaling. WNT inhibitors suppress LAPTM4B-induced CD133<sup>+</sup> CSLC stemness. Thus, targeting the LAPTM4B-WNT/β-catenin axis could improve antitumor efficacy.
Authors
- Meirong Chen (ORCID: https://orcid.org/0000-0003-4943-227X)
- Jianping Liao
- Ye Cheng
- Jiahong Wang (ORCID: https://orcid.org/0000-0001-6796-1832)
- Aimin Huang (ORCID: https://orcid.org/0000-0002-0575-8676)
Institutions
- Fujian Medical University (CN)
- Sun Yat-sen University (CN)
- Fujian Women and Children Hospital (CN)
- Quzhou City People's Hospital (CN)
- Maternity and Children's Hospital (SA)
- The 180th Hospital of PLA (CN)
- Sun Yat-sen University Cancer Center (CN)
- State Key Laboratory of Oncology in South China
Publication Details
- Journal
- JHEP Reports
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1016/j.jhepr.2024.101306
- Citations
- 2
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- State Key Laboratory of Oncology in South China
- Fujian Medical University