T cell immune senescence is associated with frailty and sarcopenia in lung transplant candidates
These findings suggest that impaired cell-mediated immunity may underlie the associations between frailty and sarcopenia and poor clinical outcomes. A multifaceted approach to evaluation of older patients has the potential to improve risk stratification and inform management of immunosuppression.
Authors
- D. Sayah (ORCID: https://orcid.org/0000-0001-7021-8273)
- Harry Pickering (ORCID: https://orcid.org/0000-0003-2348-5410)
- John A. Belperio (ORCID: https://orcid.org/0000-0003-2379-5486)
- Kathleen Ruchalski (ORCID: https://orcid.org/0000-0001-7988-8484)
- Benjamin Seligman (ORCID: https://orcid.org/0000-0002-8223-5924)
- Maura Rossetti
- A. Ardehali (ORCID: https://orcid.org/0000-0003-2856-6041)
- Elaine F. Reed (ORCID: https://orcid.org/0000-0002-3524-545X)
- Reshma Biniwale (ORCID: https://orcid.org/0000-0002-2409-0907)
- Joanna Schaenman (ORCID: https://orcid.org/0000-0003-1174-3961)
- Michael Y. Shino (ORCID: https://orcid.org/0000-0001-9261-1404)
- Ashley E. Prosper (ORCID: https://orcid.org/0000-0001-8615-5246)
- Ashley Hu (ORCID: https://orcid.org/0000-0003-0310-2742)
- S. Samuel Weigt
Institutions
- University of California, Los Angeles (US)
- University of California System (US)
Publication Details
- Journal
- JHLT Open
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1016/j.jhlto.2024.100199
- Citations
- 2
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- National Institutes of Health
- National Center for Advancing Translational Sciences