The assessment of the relationship between the development of cardiovascular diseases and SCUBE-1 level in individuals exposed to loud noise

Development of industry in the modern world, the number of individuals working in noisy environments is increasing with each passing day. Noise causes an increase in the incidence of cardioembolic events, yet the relevant underlying pathophysiology remains unclear. In this study, we aimed to investigate the relationship between signal peptide and complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein-1 (SCUBE-1) in the pathophysiology of cardioembolic events in individuals exposed to noisy environments. The study sample consisted of 99 textile factory workers who were exposed to loud noise and 56 volunteer office workers who were not exposed to loud noise. Hemogram values, basic biochemical parameters, and SCUBE-1 levels were measured for all participants. When the SCUBE-1 level of the group exposed to loud noise was compared with the control group, SCUBE-1 level was found to be significantly higher in the group exposed to loud noise (P < .001). The group exposed to loud noise was divided into 2 subgroups based on the duration of exposure to loud noise. The SCUBE-1 levels were significantly higher in the group exposed to loud noise for >10 years than in the group exposed to loud noise for <10 years (P < .001). In this study, we found that noise significantly increased the serum SCUBE-1 levels. Noise was also an independent predictor of serum signal peptide-complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein-1 levels. Therefore, it should be noted that individuals exposed to noise may be more prone to embolic events.